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An optimal stratified Simon two‐stage design
Author(s) -
Parashar Deepak,
Bowden Jack,
Starr Colin,
Wernisch Lorenz,
Mander Adrian
Publication year - 2016
Publication title -
pharmaceutical statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.421
H-Index - 38
eISSN - 1539-1612
pISSN - 1539-1604
DOI - 10.1002/pst.1742
Subject(s) - interim analysis , clinical study design , population , interim , sample size determination , clinical trial , adaptive design , research design , computer science , stratification (seeds) , population stratification , statistics , medicine , mathematics , biology , seed dormancy , biochemistry , botany , germination , environmental health , archaeology , dormancy , gene , genotype , single nucleotide polymorphism , history
In Phase II oncology trials, therapies are increasingly being evaluated for their effectiveness in specific populations of interest. Such targeted trials require designs that allow for stratification based on the participants' molecular characterisation. A targeted design proposed by Jones and Holmgren (JH) Jones CL, Holmgren E: ‘An adaptive Simon two‐stage design for phase 2 studies of targeted therapies’, Contemporary Clinical Trials 28 (2007) 654‐661.determines whether a drug only has activity in a disease sub‐population or in the wider disease population. Their adaptive design uses results from a single interim analysis to decide whether to enrich the study population with a subgroup or not; it is based on two parallel Simon two‐stage designs. We study the JH design in detail and extend it by providing a few alternative ways to control the familywise error rate, in the weak sense as well as the strong sense. We also introduce a novel optimal design by minimising the expected sample size. Our extended design contributes to the much needed framework for conducting Phase II trials in stratified medicine. © 2016 The Authors Pharmaceutical Statistics Published by John Wiley & Sons Ltd