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Practical guide to sample size calculations: superiority trials
Author(s) -
Flight Laura,
Julious Steven A.
Publication year - 2015
Publication title -
pharmaceutical statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.421
H-Index - 38
eISSN - 1539-1612
pISSN - 1539-1604
DOI - 10.1002/pst.1718
Subject(s) - sample size determination , sample (material) , computer science , statistics , advice (programming) , econometrics , mathematics , chemistry , chromatography , programming language
A sample size justification is a vital part of any investigation. However, estimating the number of participants required to give meaningful results is not always straightforward. A number of components are required to facilitate a suitable sample size calculation. In this paper, the steps for conducting sample size calculations for superiority trials are summarised. Practical advice and examples are provided illustrating how to carry out the calculations by hand and using the app SampSize. Copyright © 2015 John Wiley & Sons, Ltd.