Premium
Sample sizes for estimation in clinical research
Author(s) -
Julious Steven A.,
Patterson Scott D.
Publication year - 2004
Publication title -
pharmaceutical statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.421
H-Index - 38
eISSN - 1539-1612
pISSN - 1539-1604
DOI - 10.1002/pst.125
Subject(s) - sample size determination , estimation , confidence interval , sample (material) , statistics , computer science , clinical trial , econometrics , medical physics , psychology , operations research , medicine , mathematics , engineering , chemistry , systems engineering , chromatography , pathology
A sample size justification should be given for all clinical investigations. However, sometimes the objective of a trial is to estimate an effect with a view to planning a later definitive study. This paper describes the calculations for designing studies where one wishes to adopt an estimation approach through using confidence intervals around the overall response. Calculations are given for data anticipated to take a Normal form. Copyright © 2004 John Wiley & Sons, Ltd.