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Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons
Author(s) -
Krůšek Jan,
Dittert Ivan,
Smejkalová Tereza,
Kořínek Miloslav,
Gottfriedová Kristýna,
Freislebenová Hana,
Neuhöferová Eva,
Klimša Ladislav,
Sedláková Silvia,
Taylor Andrew,
Mortet Vincent,
Petrák Václav,
Benson Veronika,
Petráková Vladimíra
Publication year - 2019
Publication title -
physica status solidi (b)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.51
H-Index - 109
eISSN - 1521-3951
pISSN - 0370-1972
DOI - 10.1002/pssb.201800424
Subject(s) - materials science , surface modification , biocompatibility , diamond , porosity , nanotechnology , polymer , nanocrystalline material , chemical engineering , composite material , engineering , metallurgy
This article examines the ability of newly developed nanostructured porous boron‐doped diamond (BDD) to form an interface with neural cells and the role of molecular functionalization by a polymer on this interface. Due to its high stability, biocompatibility, and electrical properties, BDD is a promising material for construction of neuroelectrodes. Nanostructuring and an increase in the surface specific area can further improve the sensitivity and performance of such electrodes. Here, porous BDD prepared in a multistep diamond deposition on a porous template consisting of a polymer and electrospun SiO 2 fibers is examined. This work shows that this new material is biocompatible and does not exhibit any cytotoxicity on fibroblast cell lines. Further, this work shows that porous BDD supports regeneration of newborn and adult neurons when functionalized with poly‐L‐lysine.