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The Radiosensitizing Effect of Nanodiamonds (NDs) on HeLa Cells Under X‐Ray Irradiation
Author(s) -
Chen Xin,
Wang Hong,
Wang Hao,
Fu Yang,
Liu Jie,
Liu Runze
Publication year - 2018
Publication title -
physica status solidi (a)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 104
eISSN - 1862-6319
pISSN - 1862-6300
DOI - 10.1002/pssa.201700715
Subject(s) - hela , radiosensitivity , irradiation , cytotoxicity , cell culture , in vitro , cancer research , cell , chemistry , microbiology and biotechnology , radiochemistry , biology , biochemistry , physics , genetics , nuclear physics
In this study, the possible enhancement of radiosensitivity induced by nanodiamonds(NDs) is investigated. In this work, a potentialization of cytotoxicity after a co‐exposure to NDs and irradiation using the human cervical cancer cell line (Hela cells) is shown. The combined exposure of 100 μg ml −1 NDs and 4 Gy radiation decreases the rate of cell viability in Hela cell line as compared to each single exposure. These results show that NDs can enhance the radiosensitivity of tumor cells in vitro. Thus, the NDs could provide a new clinical strategy for radiosensitizing on cancer cells.