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A giant magnetoimpedance sensor for sensitive detection of streptavidin‐coupled Dynabeads
Author(s) -
Wang Tao,
Yang Zhen,
Lei Chong,
Lei Jian,
Zhou Yong
Publication year - 2014
Publication title -
physica status solidi (a)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 104
eISSN - 1862-6319
pISSN - 1862-6300
DOI - 10.1002/pssa.201330309
Subject(s) - streptavidin , chemistry , biochemistry , biotin
An integrated giant magnetoimpedance (GMI) sensor has been used for the detection of Dynabeads® MyOne Streptavidin C1 (DMS). An Au film was sputtered onto magnetic sensing elements for the immobilization of DMS in order to develop an integrated biosensor for potentially biomedical applications. The GMI responses were measured for the detection of DMS from 0.1 µg mL −1 to 100 µg mL −1 . We observed that the GMI effect was greatly improved at high frequencies owing to the presence of superparamagnetic beads. It was found that magnetic dipole fields had partly canceled each other out due to the uneven distributions and high‐density clusters of Dynabeads. High‐detection sensitivity was achieved in the detection of low concentrations of DMS. This integrated GMI sensor is well suited for detection of magnetic beads‐labeled biological components.