Premium
Guidance of glial cells and neurites from dorsal root ganglia by laser induced periodic patterning of biphasic core/shell nanowires
Author(s) -
Lee Juseok,
Schwarz Lukas K.,
Akkan Cagri K.,
Miró Marina M.,
Abad Oscar T.,
Schäfer KarlHerbert,
Veith Michael,
Aktas Cenk
Publication year - 2013
Publication title -
physica status solidi (a)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 104
eISSN - 1862-6319
pISSN - 1862-6300
DOI - 10.1002/pssa.201200778
Subject(s) - neurite , materials science , nanowire , fabrication , laser , dorsum , nanotechnology , adhesion , shell (structure) , biophysics , optoelectronics , anatomy , optics , chemistry , biology , composite material , in vitro , physics , medicine , biochemistry , alternative medicine , pathology
Modification of topography is an effective tool to control the cellular response such as cell function, adhesion and proliferation on surfaces. In this work, we present a novel method for fabrication of periodic surface structures by laser interference patterning (LIP) of biphasic Al/Al 2 O 3 nanowires (NWs). These structures have a periodicity of 1–8 µm and a depth of 300–600 nm, depending on the incidence angle of the laser beam. Such hierarchical structures are composed of both micro‐ and nanofeatures. These periodic patterns lead to an alignment of glial cells and an axonal guidance from cultured dorsal root ganglia (DRG), along defined directions. The most pronounced alignment was seen at a periodicity of 2 µm. (a) Random growth of neurites on as‐deposited chaotic NWs. (b) Aligned growth of neurites on patterned NWs.