Premium
Cover Picture: Phys. Status Solidi A 206/3
Publication year - 2009
Publication title -
physica status solidi (a)
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.532
H-Index - 104
eISSN - 1862-6319
pISSN - 1862-6300
DOI - 10.1002/pssa.200990002
Subject(s) - diamond , cover (algebra) , nanotechnology , computer science , materials science , art history , physics , chemistry , art , engineering , mechanical engineering , composite material
Abstract The Feature Article by Sylvia Wenmackers et al. on pp. 391–408 focuses on the development of diamond‐based DNA sensors. The physical properties of chemically vapor deposited diamond make it an appealing platform for biosensors. Stable bio‐functionalization can be achieved and various read‐out strategies can be employed, including real‐time and label‐free electronic measurements of hybridization and denaturation events. The left hand side of the cover picture shows the molecular scaffold between the diamond surface and DNA strands (with fluorescent label). This covalent coupling method allows to predetermine the location of the DNA probes using shadow masks during the attachment of the organic linker molecule under UV illumination. The right hand side of the figure shows a confocal fluorescence microscopy image of such a patterned, DNA‐modified diamond surface (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)