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Location‐dependent controlled release kinetics of model hydrophobic compounds from mesoporous silicon/biopolymer composite fibers
Author(s) -
Fan Dongmei,
Loni Armando,
Canham Leigh T.,
Coffer Jeffery L.
Publication year - 2009
Publication title -
physica status solidi (a)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 104
eISSN - 1862-6319
pISSN - 1862-6300
DOI - 10.1002/pssa.200881118
Subject(s) - polycaprolactone , biopolymer , mesoporous material , composite number , kinetics , chemical engineering , materials science , ruthenium , porosity , bipyridine , controlled release , polymer chemistry , chemistry , nanotechnology , composite material , polymer , organic chemistry , catalysis , quantum mechanics , crystal structure , engineering , physics
In this study, biodegradable mesoporous Si (BioSilicon TM ) was loaded with cis‐(2,2′‐bipyridine) dichlororuthenium (II) (Ru complex) as a model hydrophobic compound. This ruthenium complex‐loaded BioSilicon TM was either partially embedded on the surface of electrospun polycaprolactone (PCL) fibers or fully encapsulated within the fibers. To study release profiles in the above model delivery systems, porous Si/PCL constructs were soaked in DI water at 37 °C and the UV–Vis absorption spectrum of the supernatant was measured as a function of time. These results show that the Ru complex was released in a sustained manner over 7‐day period. In addition, it is shown that the controlled‐release of this complex depends on both the spatial location of the complex in the PCL fibrous scaffolds as well as the amount of Ru compound loaded in the mesoporous Si. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)