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Novel applications of silicon and porous silicon based EISCAP biosensors
Author(s) -
Mathew Arun,
Pandian Ganesh,
Bhattacharya Enakshi,
Chadha Anju
Publication year - 2009
Publication title -
physica status solidi (a)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 104
eISSN - 1862-6319
pISSN - 1862-6300
DOI - 10.1002/pssa.200881084
Subject(s) - biosensor , tributyrin , porous silicon , silicon , potentiometric titration , silicon oxide , materials science , chemistry , oxide , silicon nitride , linear range , chromatography , lipase , electrode , nanotechnology , detection limit , optoelectronics , organic chemistry , enzyme
We report the fabrication of potentiometric electrolyte‐insulator capacitor (EISCAP) biosensors based on silicon and porous silicon (PS) substrates with oxide and stacked oxide‐nitride dielectrics. These biosensors have been calibrated for the detection and estimation of bioanalytes like tributyrin and urea, based on enzymatic reactions and have a linear detection range from 0.1 mM to 20 mM of the bioanalyte concentration. These improved sensitivity EISCAP sensors were used for the estimation of the total acid content in rancid butter, estimation of enzyme (Lipase) activity and to estimate total triglyceride levels in blood serum. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)