Cell micro‐arrays from surface‐attached peptide‐polymer monolayers | Zendy

Petersen Sönke | Zendy; Loschonsky Sidar | Zendy; Prucker Oswald | Zendy; Rühe Jürgen | Zendy; Biesalski Markus | Zendy

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Cell micro‐arrays from surface‐attached peptide‐polymer monolayers

Author(s) -

Petersen Sönke,

Loschonsky Sidar,

Prucker Oswald,

Rühe Jürgen,

Biesalski Markus

Publication year - 2009

Publication title -

physica status solidi (a)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.532

H-Index - 104

eISSN - 1862-6319

pISSN - 1862-6300

DOI - 10.1002/pssa.200880484

Subject(s) - monolayer , polymer , materials science , peptide , cell adhesion , adhesion , lithography , copolymer , nanotechnology , self assembled monolayer , surface modification , characterization (materials science) , planar , microstructure , chemistry , optoelectronics , composite material , biochemistry , computer science , computer graphics (images)

We introduce the design of a chip for the controlled adhesion of anchorage‐dependent cells. A hybrid copolymer, comprising the peptide cell‐recognition motif RGD, attached to a protein‐repellent poly(dimethylacrylamide) PDMAA polymer is used in a lithography process to implement a chemical microstructure on planar surfaces. The characterization of the surface‐attached film along with a first study of its performance in cell adhesion assays is presented. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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