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Cell micro‐arrays from surface‐attached peptide‐polymer monolayers
Author(s) -
Petersen Sönke,
Loschonsky Sidar,
Prucker Oswald,
Rühe Jürgen,
Biesalski Markus
Publication year - 2009
Publication title -
physica status solidi (a)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 104
eISSN - 1862-6319
pISSN - 1862-6300
DOI - 10.1002/pssa.200880484
Subject(s) - monolayer , polymer , materials science , peptide , cell adhesion , adhesion , lithography , copolymer , nanotechnology , self assembled monolayer , surface modification , characterization (materials science) , planar , microstructure , chemistry , optoelectronics , composite material , biochemistry , computer science , computer graphics (images)
Abstract We introduce the design of a chip for the controlled adhesion of anchorage‐dependent cells. A hybrid copolymer, comprising the peptide cell‐recognition motif RGD, attached to a protein‐repellent poly(dimethylacrylamide) PDMAA polymer is used in a lithography process to implement a chemical microstructure on planar surfaces. The characterization of the surface‐attached film along with a first study of its performance in cell adhesion assays is presented. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)