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Porous silicon substrates for neurons culturing and bio‐photonic sensing
Author(s) -
deLeon S. BenTabou,
Oren R.,
Spira M. E.,
Korbakov N.,
Yitzchaik S.,
Sa'ar A.
Publication year - 2005
Publication title -
physica status solidi (a)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 104
eISSN - 1862-6319
pISSN - 1862-6300
DOI - 10.1002/pssa.200461136
Subject(s) - porous silicon , silicon , photonics , aplysia , materials science , porous medium , nanotechnology , porosity , membrane , photoluminescence , voltage , optoelectronics , silicon photonics , chemistry , biology , composite material , neuroscience , electrical engineering , engineering , biochemistry
In this work we report on culturing of Aplysia neurons and vertebrate cells to porous silicon substrates and on the first steps toward characterizing porous silicon as a biosensor of neural activity. Neurons cultured on porous silicon substrates survived for at least one week showing normal passive membrane properties and generation of action potentials. We have investigated several mechanisms that take advantage of the optical properties of porous silicon for transducing both electrical and chemical neuronal activities into photonic signals. For example, the photoluminescence response to voltage and the reflectivity response to chemical changes were investigated. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)