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ing and Indexing • Embase (Elsevier) • SCOPUS (Elsevier) Society Information Founded in 1900, the American Society for Clinical Pharmacology and Therapeutics (ASCPT) is a scientific society dedicated to improving the understanding and use of existing drug therapies and developing better and safer treatments for the future. With more than 2,000 professionals whose primary interest is to promote and advance the science of human pharmacology and therapeutics, the society is the largest scientific and professional organization serving the discipline of clinical pharmacology. To learn more, or to apply for membership, visit: www.ascpt.org All articles published in this journal are made available under the terms of the Creative Commons Attribution License. Permission is therefore not required for academic or commercial reuse, provided that full attribution is included in the new work. Disclaimer The Publisher, Society and Editors cannot be held responsible for errors or any consequences arising from the use of information contained in this journal; the views and opinions expressed do not necessarily reflect those of the Publisher, Society and Editors, neither does the publication of advertisements constitute any endorsement by the Publisher, Society and Editors of the products advertised. Publisher CPT: Pharmacometrics & Systems Pharmacology is published by Wiley Periodicals, Inc., 350 Main Street, Malden, MA 02148; Telephone: 781-388-8200; Fax: 781-388-8210.