Open AccessBest Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network
Author(s) -
CucurullSanchez Lourdes,
Chappell Michael J.,
Chelliah Vijayalakshmi,
Amy Cheung S. Y.,
Derks Gianne,
Penney Mark,
Phipps Alex,
MalikSheriff Rahuman S.,
Timmis Jon,
Tindall Marcus J.,
Graaf Piet H.,
Vicini Paolo,
Yates James W. T.
Publication year - 2019
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12381
Subject(s) - systems pharmacology , standardization , computer science , risk analysis (engineering) , set (abstract data type) , reusability , reuse , management science , engineering , pharmacology , medicine , programming language , drug , software , waste management , operating system
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermines the potential impact of QSP in academic, industrial, and regulatory frameworks. This article presents a minimum set of recommendations from the UK Quantitative and Systems Pharmacology Network (UK QSP Network) to guide QSP practitioners seeking to maximize their impact, and stakeholders considering the use of QSP models in their environment.