Open AccessEstablishing a Multidisciplinary Framework to Study Drug‐Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate
Author(s) -
Lesko Lawrence J.,
Vozmediano Valvanera,
Brown Joshua D.,
Winterstein Almut,
Zhao Ping,
Lippert Jörg,
Höchel Joachim,
Chaturvedula Ayyappa,
White Annesha,
Schmidt Stephan
Publication year - 2018
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12357
Subject(s) - multidisciplinary approach , drug , medicine , hormonal contraception , pharmacology , intensive care medicine , family planning , political science , research methodology , population , environmental health , law
Hormonal contraceptive agents ( HCA s) are widely used throughout the world, and women taking HCA s are likely to take other medications. However, little is known about the clinical effect of most drug‐drug interactions ( DDI s) associated with HCA s. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI ‐prediction framework to inform optimal use of HCA s.