Open AccessCrowdsourced Asparagus Urinary Odor Population Kinetics
Author(s) -
Ramamoorthy Anuradha,
Sadler Brian M.,
van Hasselt J.G. Coen,
ElassaissSchaap Jeroen,
Kasichayanula Sreeneeranj,
Edwards Alena Y.,
van der Graaf Piet H.,
Zhang Lei,
Wagner John A.
Publication year - 2018
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12264
Subject(s) - asparagus , urine , odor , medicine , odds , population , urinary system , zoology , horticulture , psychology , environmental health , biology , logistic regression , neuroscience
The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV). To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with consenting attendees from two American Society for Clinical Pharmacology and Therapeutics (ASCPT) meetings. Subjects were randomized to eat a specific number of asparagus spears, and then asked to report their urinary odor perception. Eighty‐seven subjects were included in the final analysis. A mixed effect proportional odds model was developed that adequately characterized the dose‐response relationship. We estimated the half‐life of the asparagus effect on malodorous urine to be 4.7 hours (relative standard error (RSE) = 13.2%), and identified a dose‐response slope term with good precision (24.3%). Age was found as the predictor of IIV in slope estimates. This study design and tools can be used as a demonstration “crowdsourcing” project for studying population kinetics in organizational and educational settings.