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New α,γ‐cyclic peptides‐nanotube molecular caps using α,α‐dialkylated α‐amino acids
Author(s) -
Reiriz César,
Castedo LUIS,
Granja Juan R.
Publication year - 2008
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.984
Subject(s) - peptide , amino acid , chemistry , hydrogen bond , cyclic peptide , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , molecule
Abstract We report here the preparation and structural characteristics of a novel self‐assembling peptide composed of alternating α,α‐dialkylated α‐amino and cis ‐4‐aminocyclopent‐2‐enecarboxylic acids. The use of α,α‐dialkylated amino acids represents a novel method to prevent the formation of extensive β‐sheet‐like hydrogen‐bonding networks that are characteristic of peptide nanotubes. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.