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Bioinformatics‐based discovery and identification of new biologically active peptides for GPCR deorphanization
Author(s) -
Colette Jean,
Avé Emilie,
GrenierBoley Benjamin,
Coquel AnneSophie,
Lesellier Karine,
Puget Karine
Publication year - 2007
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.898
Subject(s) - g protein coupled receptor , computational biology , drug discovery , identification (biology) , drug development , bioinformatics , biology , receptor , drug , pharmacology , biochemistry , botany
Owing to their involvement in many physiological and pathological processes, G‐protein‐coupled receptors (GPCRs) are interesting targets for drug development. Approximately, 100 endoGPCRs lack their natural ligands and remain orphan (oGPCRs). Consequently, oGPCR deorphanization appears a promising research field for the development of new therapeutics. On the basis of the knowledge of currently known GPCR/ligand couples, some oGPCRs may be targeted by peptides. However, to find new drugs for GPCRs, Genepep has developed a dedicated bioinformatics platform to screen transcriptomic databases for the prediction of new GPCR ligands. The peptide lists generated include specific data, such as chemical and physical properties, the occurrence of post‐translational modifications (PTMs) and an annotation referring to the location and expression level of the related putative genes. This information system allows a selection through series of biological criteria of ∼10 000 natural peptides including already known GPCR ligands and potential new candidates for GPCR deorphanization. The most promising peptides for functional assay screening and future development as therapeutic agents are under evaluation. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.