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Soft shell resins for solid‐phase peptide synthesis
Author(s) -
Lee TaeKyung,
Choi JeongHyun,
Ryoo SunJong,
Lee YoonSik
Publication year - 2007
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.897
Subject(s) - divinylbenzene , suspension polymerization , polystyrene , peptide , shell (structure) , swelling , polymer chemistry , polymerization , phase (matter) , chemistry , layer (electronics) , chemical engineering , materials science , composite material , organic chemistry , copolymer , styrene , polymer , biochemistry , engineering
Soft shell (SS) resins with a lightly or noncross‐linked shell layer were prepared by reducing the amount of cross‐linking agent, divinylbenzene (DVB), during seed suspension polymerization from polystyrene (PS) resin. These SS resins have a lower swelling volume than that produced by normal cross‐linking. Despite its lower swelling, however, SS (10–00) resin, which consists of the 1% DVB‐cross‐linked core and the noncross‐linked surface layer, showed higher efficiency in peptide synthesis compared with 1% DVB‐PS resin and other SS resins. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.