Synthesis of lipophilic 2‐oxoamides based on γ‐aminobutyric and δ‐aminovaleric analogues and their activity against phospholipase A 2 | Zendy

MoutevelisMinakakis Panagiota | Zendy; Neokosmidi Afroditi | Zendy; Filippakou Maria | Zendy; Stephens Daren | Zendy; Dennis Edward A. | Zendy; Kokotos George | Zendy

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Synthesis of lipophilic 2‐oxoamides based on γ‐aminobutyric and δ‐aminovaleric analogues and their activity against phospholipase A 2

Author(s) -

MoutevelisMinakakis Panagiota,

Neokosmidi Afroditi,

Filippakou Maria,

Stephens Daren,

Dennis Edward A.,

Kokotos George

Publication year - 2007

Publication title -

journal of peptide science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 66

eISSN - 1099-1387

pISSN - 1075-2617

DOI - 10.1002/psc.889

Subject(s) - phosphonate , chemistry , tetrazole , phospholipase a2 , stereochemistry , phospholipase a , biochemistry , enzyme

A variety of lipophilic 2‐oxoamides based on γ‐aminobutyric and δ‐aminovaleric analogues were synthesized. 2‐oxoamides containing a tetrazole, a thioethyl or a thioacetyl group are weak inhibitors of GIVA cPLA 2 , while derivatives containing a methyl tetrazole, a diethyl phosphonate or a thioethyl group are weak inhibitors of GV sPLA 2 . Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.

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