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Synthesis of lipophilic 2‐oxoamides based on γ‐aminobutyric and δ‐aminovaleric analogues and their activity against phospholipase A 2
Author(s) -
MoutevelisMinakakis Panagiota,
Neokosmidi Afroditi,
Filippakou Maria,
Stephens Daren,
Dennis Edward A.,
Kokotos George
Publication year - 2007
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.889
Subject(s) - phosphonate , chemistry , tetrazole , phospholipase a2 , stereochemistry , phospholipase a , biochemistry , enzyme
A variety of lipophilic 2‐oxoamides based on γ‐aminobutyric and δ‐aminovaleric analogues were synthesized. 2‐oxoamides containing a tetrazole, a thioethyl or a thioacetyl group are weak inhibitors of GIVA cPLA 2 , while derivatives containing a methyl tetrazole, a diethyl phosphonate or a thioethyl group are weak inhibitors of GV sPLA 2 . Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.