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Intraoral administration of a T‐cell epitope peptide induces immunological tolerance in Cry j 2‐sensitized mice
Author(s) -
Yoshitomi Tomomi,
Nakagami Yasuhiro,
Hirahara Kazuki,
Taniguchi Yoshifumi,
Sakaguchi Masahiro,
Yamashita Makoto
Publication year - 2007
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.869
Subject(s) - immune tolerance , immunotherapy , immune system , epitope , immunology , medicine , oral administration , t cell , allergen , peptide , cryptomeria , sublingual administration , pharmacology , antibody , biology , allergy , japonica , biochemistry , botany
Sublingual immunotherapy using allergen‐derived peptides is feasible as a novel specific immunotherapy, but its efficacy has not yet been demonstrated in either humans or animals. In addition, it remains obscure whether the oral immune system is involved in the mechanism of sublingual immunotherapy. Here, we show that the intraoral administration of the T‐cell epitope peptide P2‐246‐259 derived from Cry j 2, a major Japanese cedar ( Cryptomeria japonica ) pollen allergen, to Cry j 2‐sensitized mice induces immunological tolerance, and that ex vivo lymph node cell proliferation to P2‐246‐259 and Cry j 2 was inhibited. In addition, intraoral administration was shown to be superior to intragastric administration in terms of tolerance induction, suggesting that the oral immune system contributes to the induction of immunological tolerance. Therefore, the significant efficacy of sublingual immunotherapy using a peptide on allergen‐specific T‐cells was demonstrated in animals, and this may be potentiated by the oral mucosal immune system. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.