Synthesis of analogues of anthraquinones linked to tuftsin or retro‐tuftsin residues as potential topoisomerase inhibitors | Zendy

Dzierzbicka K. | Zendy; Sowinski P. | Zendy; Kołodziejczyk A. M. | Zendy

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Synthesis of analogues of anthraquinones linked to tuftsin or retro‐tuftsin residues as potential topoisomerase inhibitors

Author(s) -

Dzierzbicka K.,

Sowinski P.,

Kołodziejczyk A. M.

Publication year - 2006

Publication title -

journal of peptide science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 66

eISSN - 1099-1387

pISSN - 1075-2617

DOI - 10.1002/psc.777

Subject(s) - tuftsin , chemistry , oxazole , anthraquinones , peptide , pharmacology , stereochemistry , oligopeptide , cell culture , anthraquinone , biochemistry , biology , organic chemistry , botany , genetics

A novel group of [(4‐, 5‐ or 8)‐hydroxy‐9,10‐anthraquinone‐1‐yl]‐(tuftsin or retro‐tuftsin) acids and methyl esters has been synthesized as potential anticancer compounds. The corresponding protected tuftsin or retro‐tuftsin derivatives were also synthesized. We hope that combining compounds of different mechanisms of action will improve their clinical properties, and that our new analogues will be much more effective against multidrug‐resistant tumour cell lines. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd.

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