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Synthesis of analogues of anthraquinones linked to tuftsin or retro‐tuftsin residues as potential topoisomerase inhibitors
Author(s) -
Dzierzbicka K.,
Sowinski P.,
Kołodziejczyk A. M.
Publication year - 2006
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.777
Subject(s) - tuftsin , chemistry , oxazole , anthraquinones , peptide , pharmacology , stereochemistry , oligopeptide , cell culture , anthraquinone , biochemistry , biology , organic chemistry , botany , genetics
A novel group of [(4‐, 5‐ or 8)‐hydroxy‐9,10‐anthraquinone‐1‐yl]‐(tuftsin or retro‐tuftsin) acids and methyl esters has been synthesized as potential anticancer compounds. The corresponding protected tuftsin or retro‐tuftsin derivatives were also synthesized. We hope that combining compounds of different mechanisms of action will improve their clinical properties, and that our new analogues will be much more effective against multidrug‐resistant tumour cell lines. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd.