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Structure activity relationship studies on the antimicrobial activity of novel edeine A and D analogues
Author(s) -
Czajgucki Zbigniew,
Andruszkiewicz Ryszard,
Kamysz Wojciech
Publication year - 2006
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.775
Subject(s) - moiety , tripeptide , dipeptide , pentapeptide repeat , chemistry , stereochemistry , biological activity , amino acid , combinatorial chemistry , antimicrobial , residue (chemistry) , amide , peptide bond , peptide synthesis , peptide , biochemistry , organic chemistry , in vitro
Edeines are pentapeptide amide antibiotics composed of four nonprotein amino acids, glycine, and polyamine. They exhibit antimicrobial and immunosuppressive activities and are universal inhibitors of translation. Moreover, it was proven that the free ionizable carboxy group in the (2 R , 6 S , 7 R )‐2,6‐diamino‐7‐hydroxyazelaic acid moiety is not essential for biological activity of these compounds. In this paper we describe the synthesis of four novel edeine A and D analogues in which the above‐mentioned acid residue was replaced with the (3 R , 4 S )‐ or (3 S , 4 S )‐4,5‐diamino‐3‐hydroxypentanoic acid moiety. In one compound we also introduced into molecule the 3‐ N , N ‐dimethyl derivative of ( S )‐2,3‐diaminopropanoic acid to prevent the transpeptidation process, which results in the loss of biological activity of α‐isomers of edeines. All peptides were synthesized applying the active ester and azide methods and on the basis of the coupling of suitable N ‐terminal tripeptides with proper C ‐terminal dipeptide amides. The activities of the newly obtained edeine analogues against selected strains of bacteria and fungi are also presented. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd.