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Peptide vector for gene delivery with high affinity for phosphatidylserine
Author(s) -
Kuriyama Shinichi,
Taguchi Yasushi,
Nishimura Kanako,
Mizuguchi Kiyoshi,
Kobayashi Kazutoshi,
Katayama Yoshiki,
Yanagibashi Kazutoshi,
Niidome Takuro
Publication year - 2006
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.768
Subject(s) - phosphatidylserine , gene delivery , vector (molecular biology) , chemistry , peptide , gene , computational biology , microbiology and biotechnology , genetic enhancement , biology , biochemistry , recombinant dna , membrane , phospholipid
Since phosphatidylserine (PS) is known to translocate to the external face of the plasma membrane when the cell membrane becomes disordered, we decided to focus our attention on PS as a target molecule for gene delivery. In this paper, the novel peptide Td3701 was designed, synthesized, and characterized for its physico‐chemico‐biological properties. Td3701 simultaneously exhibited both characters as a DNA carrier and a sensor probe for active targeting, which seemed to be triggered by structural changes in the presence of PS. This is a very unique character among nonviral vectors, and it is believed that Td3701 could be used for selective gene delivery. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd.