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Cyclic oligomers of oxetane‐based dipeptide isosteres derived from L ‐rhamnose
Author(s) -
Fleet George W. J.,
Johnson Stephen W.,
Jones John H.
Publication year - 2006
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.759
Subject(s) - oxetane , dipeptide , chemistry , rhamnose , stereochemistry , organic chemistry , amino acid , biochemistry , polysaccharide
Two new cyclic oligomers, cyclo‐tetra‐[2,4‐anhydro‐3‐ O ‐ tert ‐butyldimethylsilyl‐5‐deoxy‐ L ‐rhamnonamido‐( N →5)] and the corresponding 6‐deoxy‐ D ‐gulonate cyclic ‘tetramer’, have been synthesised from linear tetrameric oligomers, using TBTU‐ and pentafluorophenyl ester–based methodologies, respectively. These two compounds constitute a novel class of cyclic oligomers derived from oxetane‐based sugar amino acids. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd.