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Facile synthesis of phosphonamidate‐ and phosphonate‐linked phosphonopeptides
Author(s) -
Fu Nanyan,
Zhang Qihan,
Duan Lifang,
Xu Jiaxi
Publication year - 2006
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.727
Subject(s) - phosphonate , aminolysis , chemistry , carbamate , organic chemistry , combinatorial chemistry , peptide synthesis , peptide , catalysis , biochemistry
A direct method for the preparation of phosphonamidate‐ and phosphonate‐linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one‐pot reactions of benzyl carbamate, aldehydes, and methyl dichlorophosphite, followed by aminolysis with amino acid esters or alcoholysis with hydroxy esters. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.