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The first synthesis of chiral PNA monomer‐cyclen conjugates
Author(s) -
Ma LiJian,
Zhang GuoLin,
Chen ShanYong,
Wu Bo,
You JingSong,
Xia ChuanQin,
Yu XiaoQi
Publication year - 2005
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.685
Subject(s) - cyclen , monomer , chemistry , conjugate , uracil , combinatorial chemistry , aqueous solution , stereochemistry , organic chemistry , polymer , biochemistry , dna , mathematical analysis , mathematics
A synthetic route to novel chiral PNA monomer‐cyclen conjugates was described for the first time, the targeted products were obtained in high yields under mild reaction conditions. The preliminary results demonstrated that the uracil‐PNA monomer‐cyclen conjugates can rapidly bind Zn 2+ in aqueous solution, and the structure of the Zn(II) complex was confirmed facilely by HRMS spectra, 1 H NMR spectra and elemental analysis. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.