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Current Concepts in Intestinal Peptide Absorption
Author(s) -
Fricker Gert,
Drewe Jürgen
Publication year - 1996
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.66
Subject(s) - absorption (acoustics) , peptide , current (fluid) , chemistry , biochemistry , physics , optics , thermodynamics
Today there is considerable interest in oral peptide delivery. However, oral administration of peptides is limited by a low bioavailability and a high variability in plasma levels. A review is given of the literature describing the major barriers in peptide absorption, the basic mechanisms of intestinal peptide transport, the experimental models and the pharmaceutical approaches currently used in the investigation of peptide and protein absorption processes.