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Contribution of the functional dyad of animal toxins acting on voltage‐gated Kv1‐type channels
Author(s) -
Mouhat Stephanie,
De Waard Michel,
Sabatier JeanMarc
Publication year - 2005
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.630
Subject(s) - dyad , ion channel , chemistry , amino acid residue , block (permutation group theory) , computational biology , biochemistry , biology , peptide sequence , psychology , receptor , social psychology , geometry , mathematics , gene
Abstract The ‘functional dyad’, a well‐defined pair of amino acid residues (basic and hydrophobic residues), is a key molecular determinant present in most animal toxins acting on voltage‐gated Kv1 channels. It is increasingly used as a working concept to explain how toxins are able to recognize and block their specific ion channel targets. However, other crucial toxin determinants are emerging and the actual role of this ‘functional dyad’ ought to be clarified, which is the object of the present mini‐review. Copyright © 2004 European Peptide Society and John Wiley & Sons, Ltd.