Synthesis and activity of 2‐oxoamides containing long chain β‐amino acids | Zendy

ConstantinouKokotou Violetta | Zendy; Peristeraki Anna | Zendy; Kokotos Christoforos G. | Zendy; Six David A. | Zendy; Dennis Edward A. | Zendy

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Synthesis and activity of 2‐oxoamides containing long chain β‐amino acids

Author(s) -

ConstantinouKokotou Violetta,

Peristeraki Anna,

Kokotos Christoforos G.,

Six David A.,

Dennis Edward A.

Publication year - 2005

Publication title -

journal of peptide science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 66

eISSN - 1099-1387

pISSN - 1075-2617

DOI - 10.1002/psc.628

Subject(s) - chemistry , amino acid , oxidative phosphorylation , chain (unit) , combinatorial chemistry , stereochemistry , biochemistry , physics , astronomy

2‐Oxoamides based on long chain β‐amino acids were synthesized. 1‐Benzyl substituted long chain amines, needed for such synthesis, were synthesized starting from Boc‐phenylalaninol. The oxidative conversion of a phenyl group to a carboxyl group was used as the key transformation synthetic step. The compounds synthesized were studied for their activity against GIVA PLA 2 , and were proven to be weak inhibitors. Copyright © 2004 European Peptide Society and John Wiley & Sons, Ltd.

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