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Synthesis and activity of 2‐oxoamides containing long chain β‐amino acids
Author(s) -
ConstantinouKokotou Violetta,
Peristeraki Anna,
Kokotos Christoforos G.,
Six David A.,
Dennis Edward A.
Publication year - 2005
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.628
Subject(s) - chemistry , amino acid , oxidative phosphorylation , chain (unit) , combinatorial chemistry , stereochemistry , biochemistry , physics , astronomy
2‐Oxoamides based on long chain β‐amino acids were synthesized. 1‐Benzyl substituted long chain amines, needed for such synthesis, were synthesized starting from Boc‐phenylalaninol. The oxidative conversion of a phenyl group to a carboxyl group was used as the key transformation synthetic step. The compounds synthesized were studied for their activity against GIVA PLA 2 , and were proven to be weak inhibitors. Copyright © 2004 European Peptide Society and John Wiley & Sons, Ltd.