Preparation of cyclic peptide libraries using intramolecular oxime formation | Zendy

Roberts Kade D. | Zendy; Lambert John N. | Zendy; Ede Nicholas J. | Zendy; Bray Andrew M. | Zendy

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Preparation of cyclic peptide libraries using intramolecular oxime formation

Author(s) -

Roberts Kade D.,

Lambert John N.,

Ede Nicholas J.,

Bray Andrew M.

Publication year - 2004

Publication title -

journal of peptide science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 66

eISSN - 1099-1387

pISSN - 1075-2617

DOI - 10.1002/psc.575

Subject(s) - oxime , hydroxylamine , cyclic peptide , intramolecular force , chemistry , ketone , peptide , combinatorial chemistry , stereochemistry , side chain , organic chemistry , biochemistry , polymer

A new method for the synthesis of cyclic head‐to‐side chain peptide libraries has been developed in which the key cyclization step involves reaction between a C ‐terminal ketone and an N ‐terminal hydroxylamine to form a macrocyclic oxime. This methodology efficiently delivers cyclic products that consist of mixtures of syn and anti isomers. Copyright © 2004 European Peptide Society and John Wiley & Sons, Ltd.

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