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Effect of humanin analogues on experimentally induced impairment of spatial memory in rats
Author(s) -
Krejcova Gabriela,
Patocka Jiri,
Slaninova Jirina
Publication year - 2004
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.569
Subject(s) - memory impairment , in vivo , neuroscience , cholinergic , in vitro , quinuclidinyl benzilate , pharmacology , chemistry , psychology , receptor , biology , muscarinic acetylcholine receptor , biochemistry , cognition , microbiology and biotechnology
Abstract Humanin and its analogues have been shown to protect cells against death induced by various Alzheimer's disease genes and amyloid‐β‐peptides in vitro; the analogue [Gly 14 ]‐humanin has also been shown to be potent in reversing learning and memory impairment induced by scopolamine in mice in vivo . It is important to validate these results by using other behavioral methods. In this study, the effect of [Gly 14 ]‐humanin and des‐Leu‐PAGA, another analogue (0.2 µmol kg −1 , i.p.) on the 3‐quinuclidinyl benzilate‐induced (2 mg kg −1 , i.p.) impairment of spatial memory in the multiple T‐maze in rats has been evaluated. Both peptides reversed the impairment of spatial memory. These results indicate the potential of humanin analogues in modulation of the cholinergic system. Copyright © 2004 European Peptide Society and John Wiley & Sons, Ltd.