Transition state isosteres of the γ‐glutamyl peptide bond hydrolysis: synthesis and characterization of the ψ[CH 2 NH] pseudopeptide analogue of glutathione | Zendy

Cacciatore Ivana | Zendy; Stefano Antonio Di | Zendy; Luisi Grazia | Zendy; Pinnen Francesco | Zendy; Sozio Piera | Zendy

Premium

Transition state isosteres of the γ‐glutamyl peptide bond hydrolysis: synthesis and characterization of the ψ[CH 2 NH] pseudopeptide analogue of glutathione

Author(s) -

Cacciatore Ivana,

Stefano Antonio Di,

Luisi Grazia,

Pinnen Francesco,

Sozio Piera

Publication year - 2004

Publication title -

journal of peptide science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 66

eISSN - 1099-1387

pISSN - 1075-2617

DOI - 10.1002/psc.501

Subject(s) - isostere , chemistry , glutathione , peptide , hydrolysis , transition state analog , stereochemistry , peptide bond , oligopeptide , combinatorial chemistry , organic chemistry , enzyme , biochemistry , active site

The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the γ‐Glu‐Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research