Premium
Isolation, structure elucidation and biological activities of trichofumins A, B, C and D, new 11 and 13mer peptaibols from Trichoderma sp. HKI 0276
Author(s) -
Berg Albrecht,
Grigoriev Pavel A.,
Degenkolb Thomas,
Neuhof Torsten,
Härtl Albert,
Schlegel Brigitte,
Gräfe Udo
Publication year - 2003
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.498
Subject(s) - chemistry , peptide , membrane , microbiology and biotechnology , biochemistry , biology
Abstract Trichofumins A–D were isolated from cultures of Trichoderma sp. HKI 0276 as new 11 and 13mer peptaibols. Similar to 15mer peptaibols they promote morphogenesis of the fungus Phoma destructiva and cause hypothermia in mice as a characteristic of neuroleptic activity. Membrane measurements using a synthetic BLM model showed that A, B, C and D increased membrane permeability for cations in a similar manner as was shown for larger peptaibols but with comparably lower efficiency. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.