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Solid‐phase synthesis: a paradigm shift
Author(s) -
Marshall Garland R.
Publication year - 2003
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.478
Subject(s) - solid phase synthesis , organic synthesis , paradigm shift , chemistry , phase (matter) , combinatorial chemistry , nanotechnology , materials science , organic chemistry , catalysis , biochemistry , philosophy , epistemology , peptide
A personal review by the first graduate student of Professor R. Bruce Merrifield of the evolution of solid‐phase synthesis and its acceptance by various subsets of the chemistry community. Solid‐phase synthesis, as currently practised in the synthesis of biopolymers, combinatorial solid‐phase organic chemistry, synthesis of natural products, catalyst selection, chemical ligation and materials development, has proven a paradigm shift for the chemistry community. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.