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Total chemical synthesis of enzymes
Author(s) -
Kent Stephen
Publication year - 2003
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.475
Subject(s) - enzyme , chemistry , chemical synthesis , molecule , small molecule , total synthesis , combinatorial chemistry , function (biology) , biochemistry , stereochemistry , organic chemistry , biology , in vitro , microbiology and biotechnology
The total synthesis, at will, of a wide variety of protein and enzyme molecules is made feasible by modern chemical ligation methods. As Emil Fischer intuitively understood, synthetic access to the enzyme molecule enables the power of chemical science to be applied to elucidating the molecular basis of catalytic function in unprecedented detail. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.