Synthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide‐, polyamide‐ and PNA‐conjugates | Zendy

Kinzel Olaf | Zendy; Fattori Daniela | Zendy; Ingallinella Paolo | Zendy; Bianchi Elisabetta | Zendy; Pessi Antonello | Zendy

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Synthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide‐, polyamide‐ and PNA‐conjugates

Author(s) -

Kinzel Olaf,

Fattori Daniela,

Ingallinella Paolo,

Bianchi Elisabetta,

Pessi Antonello

Publication year - 2003

Publication title -

journal of peptide science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 66

eISSN - 1099-1387

pISSN - 1075-2617

DOI - 10.1002/psc.463

Subject(s) - chemistry , mannose , ligand (biochemistry) , conjugate , ligation , combinatorial chemistry , polyamide , mannose receptor , solid phase synthesis , peptide , peptide synthesis , receptor , native chemical ligation , biochemistry , chemical synthesis , polymer chemistry , microbiology and biotechnology , biology , in vitro , mathematical analysis , mathematics , macrophage

The synthesis of a high affinity mannose receptor ligand, appropriately functionalized for chemoselective ligation with an antigen or DNA‐binding moieties is described. By a combination of solid‐ and solution‐phase chemistry a versatile synthesis of the target structure was accomplished. Examples of subsequent ligation reactions are described. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.

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