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Synthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide‐, polyamide‐ and PNA‐conjugates
Author(s) -
Kinzel Olaf,
Fattori Daniela,
Ingallinella Paolo,
Bianchi Elisabetta,
Pessi Antonello
Publication year - 2003
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.463
Subject(s) - chemistry , mannose , ligand (biochemistry) , conjugate , ligation , combinatorial chemistry , polyamide , mannose receptor , solid phase synthesis , peptide , peptide synthesis , receptor , native chemical ligation , biochemistry , chemical synthesis , polymer chemistry , microbiology and biotechnology , biology , in vitro , mathematical analysis , mathematics , macrophage
The synthesis of a high affinity mannose receptor ligand, appropriately functionalized for chemoselective ligation with an antigen or DNA‐binding moieties is described. By a combination of solid‐ and solution‐phase chemistry a versatile synthesis of the target structure was accomplished. Examples of subsequent ligation reactions are described. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.