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Dissecting the role of peptides in the immune response: theory, practice and the application to vaccine design
Author(s) -
Purcell Anthony W.,
Zeng Weiguang,
Mifsud Nicole A.,
Ely Lauren K.,
Macdonald Whitney A.,
Jackson David C.
Publication year - 2003
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.456
Subject(s) - immune system , peptide , computational biology , chemistry , nanotechnology , biology , combinatorial chemistry , immunology , biochemistry , materials science
Analytical biochemistry and synthetic peptide based chemistry have helped to reveal the pivotal role that peptides play in determining the specificity, magnitude and quality of both humoral (antibody) and cellular (cytotoxic and helper T cell) immune responses. In addition, peptide based technologies are now at the forefront of vaccine design and medical diagnostics. The chemical technologies used to assemble peptides into immunogenic structures have made great strides over the past decade and assembly of highly pure peptides which can be incorporated into high molecular weight species, multimeric and even branched structures together with non‐peptidic material is now routine. These structures have a wide range of applications in designer vaccines and diagnostic reagents. Thus the tools of the peptide chemist are exquisitely placed to answer questions about immune recognition and along the way to provide us with new and improved vaccines and diagnostics. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.