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Peptide related drug research
Author(s) -
Bajusz Sándor
Publication year - 2003
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.453
Subject(s) - agonist , pharmacology , drug , drug discovery , peptide , chemistry , antagonist , medicine , receptor , biochemistry
Drug discovery directed peptide research has been pursued at the IVAX Drug Research Institute (formerly Institute for Drug Research) (IDR) since the mid 1950s. Outlined are the main projects and the most significant results, which include the first synthesis of human ACTH, the discovery of GYKI‐14 166, the prototype of peptide inhibitors of thrombin, a stable anticoagulant, efegatran GYKI‐14 766, and their dual acting analogues. The identification of an agonist analogue of LHRH leading to Cetrorelix, an LHRH antagonist now in clinical use, is also presented. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.