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A 27‐mer tandem repeat polypeptide in bovine amelogenin: Synthesis and CD spectra
Author(s) -
Renugopalakrishnan V.
Publication year - 2002
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.378
Subject(s) - amelogenin , tandem repeat , chemistry , tandem , solid phase synthesis , phosphate , stereochemistry , biochemistry , peptide , gene , materials science , genome , composite material
CD spectra of a tandem 27‐mer repeat polypeptide, Gln‐Pro‐His‐Gln‐Pro‐Leu‐Gln‐Pro‐His‐Gln‐Pro‐Leu‐Gln‐Pro‐Met‐(Gln‐Pro‐Leu) 4 , from bovine amelogenin synthesized by standard solid‐phase synthesis manifests an archtypical CD pattern of a β‐spiral structure in phosphate buffer at pH 5.2 and trifluoroethanol (TFE), CF 3 OH. β‐spiral structure is unique to a class of diverse proteins including amelogenins conferring unusual physicochemical properties. Copyright © 2002 European Peptide Society and John Wiley & Sons, Ltd.