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A new water‐soluble N ‐protecting group, 2‐[phenyl(methyl)sulfonio]ethyloxycarbonyl tetrafluoroborate, and its application to solid phase peptide synthesis in water
Author(s) -
Hojo Keiko,
Maeda Mitsuko,
Kawasaki Koichi
Publication year - 2001
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.361
Subject(s) - tetrafluoroborate , protecting group , amide , chemistry , peptide synthesis , phase (matter) , peptide , solid phase synthesis , group (periodic table) , organic chemistry , ionic liquid , combinatorial chemistry , alkyl , biochemistry , catalysis
A new water‐soluble N ‐protecting group, 2‐[phenyl(methyl)sulfonio]ethyloxycarbonyl tetrafluoroborate, has been prepared and its application to solid phase peptide synthesis in water has been studied. Leu‐enkephalin amide was successfully synthesized in water by the solid phase method using this protecting group. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.