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Direct determination of the π‐helix structure and helix transition behavior of poly(β‐phenethyl l ‐aspartate) via synchrotron X‐ray diffraction
Author(s) -
Furuya Hidemine,
Yanagihara Toshinari,
Orito Yuki,
Masunaga Hiroyasu
Publication year - 2023
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.3459
Subject(s) - helix (gastropod) , crystallography , chemistry , copolymer , synchrotron , small angle x ray scattering , diffraction , x ray crystallography , side chain , stereochemistry , materials science , scattering , polymer , organic chemistry , physics , optics , ecology , snail , biology
The helix‐sense inversions of poly(β‐phenethyl l ‐aspartate) (2P) and diblock copolymers (2P‐3P), with 2P and poly(β‐phenylpropyl l ‐aspartate) (3P) blocks, were studied in their solid states using synchrotron wide‐angle X‐ray diffraction and small‐angle X‐ray scattering. The characteristic parameters of the π‐helix structure of 2P were directly determined in situ after the helix transition at a high temperature. In the 2P‐3P block copolymers, the main chains of the 3P blocks initially convert from right‐ to left‐handed α‐helices, and then the 2P blocks convert irreversibly from right‐handed α‐helices to left‐handed π‐helices. The chemical structures of the side chains of poly( l ‐aspartic acid ester)s significantly affect their helix transition behaviors.