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Insights into peptide and protein function: a convergent approach 1 2
Author(s) -
Roques Bernard P.
Publication year - 2001
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.315
Subject(s) - multicellular organism , computational biology , function (biology) , biology , division (mathematics) , peptide , microbiology and biotechnology , computer science , biochemistry , cell , mathematics , arithmetic
From viruses to multicellular organisms, life is inseparable from the genetic instructions aimed at regulating its maintenance, division, multiplication, differentiation and death (apoptosis). Over the past 15 years, structural studies have begun to resolve the complex reactions involved in these fundamental processes in biology. The three‐dimensional representations of the complexes formed with peptides and/or proteins have allowed interpretation of the biochemical data and formulation of novel hypotheses about the control and execution of these processes. Moreover, they have opened the way to rational approaches for designing compounds able to interfere with these crucial events in normal or pathological conditions. Various results obtained in our laboratory in these fields are briefly summarized in this review. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.