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Antibacterial effects of gold nanoparticles functionalized with the extracted peptide from Vespa orientalis wasp venom
Author(s) -
Jalaei Jafar,
LayeghiGhalehsoukhteh Somayeh,
Hosseini Arsalan,
Fazeli Mehdi
Publication year - 2018
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.3124
Subject(s) - colloidal gold , surface plasmon resonance , antimicrobial , peptide , venom , nanoparticle , combinatorial chemistry , antibacterial activity , chemistry , absorbance , conjugated system , nanotechnology , bacteria , materials science , biochemistry , chromatography , biology , organic chemistry , polymer , genetics
The development of novel antimicrobial strategies is necessary because of the escalation of multidrug‐resistant pathogens. Recently, antimicrobial peptides and their combination with nanoparticles were regarded as a promising tool to target drug‐resistant pathogens. Herein, we evaluated antimicrobial efficacy of a peptide extracted from Vespa orientalis wasp venom and also its conjugation with gold nanoparticles. Nanoparticle conjugation measurement was done by evaluating the absorbance changes of the surface plasmon resonance band of gold nanoparticles at 555 nm. A significant increase in the antibacterial activity against gram negative and positive bacteria was obtained when the extracted peptide conjugated with gold nanoparticles. Finally, the results show that this new peptide‐AuNps has the high practical potential for antibacterial activity and may provide an alternative therapy for bacterial infection.