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Further applications of classical amide coupling reagents: Microwave‐assisted esterification on solid phase
Author(s) -
Takayama Risa,
Hayakawa Shun,
Hinou Hiroshi,
Albericio Fernando,
GarciaMartin Fayna
Publication year - 2018
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.3111
Subject(s) - racemization , reagent , microwave irradiation , amide , solid phase synthesis , chemistry , combinatorial chemistry , microwave , peptide synthesis , phase (matter) , robustness (evolution) , organic chemistry , amino acid , peptide , computer science , biochemistry , telecommunications , gene , catalysis
Ester linkage (s) is a key chemical connector in organic chemistry, including natural products, peptides, and synthetic polymers. We herein describe a straightforward method for the efficient formation of ester linkage (s) on solid‐phase. This method simply involves the use of amide coupling reagents under microwave irradiation. The robustness of this method relies on the use of classical solid‐phase coupling reagents, heating by microwave irradiation, and a short time period, which results in high yields and the minimization of racemization.