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Inclusion volume solid‐phase synthesis
Author(s) -
Eichler Jutta,
Houghten Richard A.,
Lebl Michal
Publication year - 1996
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.310020402
Subject(s) - volume (thermodynamics) , solid phase synthesis , phase (matter) , solvent , chemistry , peptide synthesis , combinatorial chemistry , peptide , amino acid , organic chemistry , biochemistry , thermodynamics , physics
Solid‐phase synthesis of peptides was carried out using only the volume of the solvent included in the swollen solid‐phase resin beads [inclusion volume synthesis]. This approach enables (i) the use of higher concentrations of activated amino acids, resulting in increased coupling rates, (ii) drastically decreased consumption of solvents, and (iii) the construction of multiple peptide synthesizers having virtually no reaction vessels.