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Synthesis and bioactivity studies of 1‐adamantanamine derivatives of peptides
Author(s) -
Horvat Štefica,
VargaDefterdarovič Lidija,
Horvat Jaroslav,
Jukić Ruža,
Kantoci Darko,
Chung Nga N.,
Schiller Peter W.,
Biesert Lothar,
Pfützner Andreas,
Suhartono Haryadi,
RübsamenWaigmann Helga
Publication year - 1995
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.310010505
Subject(s) - syncytium , chemistry , moiety , amide , selectivity , opioid peptide , peptide , stereochemistry , receptor , cell culture , biochemistry , combinatorial chemistry , cell , opioid , biology , catalysis , genetics
Small enkephalin‐related peptides containing a 1‐adamantanamine moiety coupled through an amide linkage at the C‐terminus were synthesized. Several of the compounds showed high μ opioid activity and μ receptor selectivity. The new adamantanamine derivatives were also examined for antiviral activity against HIV‐1 in a cell culture system. Some of them inhibited syncytia formation even when the antigen assay gave evidence for viral replication.