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Synthesis and properties of the first all‐aza analogue of a biologically active peptide
Author(s) -
Gante Joachim,
Krug Michael,
Lauterbach Günter,
Weitzel Reinhard,
Hiller W.
Publication year - 1995
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.310010307
Subject(s) - biological activity , chemistry , peptide , stereochemistry , amino acid , renin inhibitor , cyclic peptide , combinatorial chemistry , biochemistry , renin–angiotensin system , biology , in vitro , blood pressure , endocrinology
The synthesis of the first all‐aza‐amino acid analogue ( 2 ) of a peptidic renin inhibitor is described. The X‐ray structural analysis and molecular modelling investigations of this novel compound reveal interesting conformational features which have a significant impact on its biological activity. In addition, insight into conformational features of azapeptides in general in comparison with the corresponding purely peptidic compounds is given.