Synthesis and properties of the first all‐aza analogue of a biologically active peptide | Zendy

Gante Joachim | Zendy; Krug Michael | Zendy; Lauterbach Günter | Zendy; Weitzel Reinhard | Zendy; Hiller W. | Zendy

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Synthesis and properties of the first all‐aza analogue of a biologically active peptide

Author(s) -

Gante Joachim,

Krug Michael,

Lauterbach Günter,

Weitzel Reinhard,

Hiller W.

Publication year - 1995

Publication title -

journal of peptide science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 66

eISSN - 1099-1387

pISSN - 1075-2617

DOI - 10.1002/psc.310010307

Subject(s) - biological activity , chemistry , peptide , stereochemistry , amino acid , renin inhibitor , cyclic peptide , combinatorial chemistry , biochemistry , renin–angiotensin system , biology , in vitro , blood pressure , endocrinology

The synthesis of the first all‐aza‐amino acid analogue ( 2 ) of a peptidic renin inhibitor is described. The X‐ray structural analysis and molecular modelling investigations of this novel compound reveal interesting conformational features which have a significant impact on its biological activity. In addition, insight into conformational features of azapeptides in general in comparison with the corresponding purely peptidic compounds is given.

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