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Properties and applications of the (2‐nitrofluoren‐9‐yl)methoxycarbonyl group
Author(s) -
Henkel Bernd,
Bayer Ernst
Publication year - 2001
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.309
Subject(s) - cleavage (geology) , lability , chemistry , stereochemistry , solvent , protecting group , medicinal chemistry , organic chemistry , materials science , alkyl , fracture (geology) , composite material
This paper presents a new protecting group, the (2‐nitrofluoren‐9‐yl)methoxycarbonyl group. Investigations on the properties of this new modification of the Fmoc‐system, such as the solvent‐dependant photochemical cleavage, and enhanced lability towards bases, are described, as well as UV‐kinetic measurements of the cleavage reaction. In addition, the incorporation of the (2‐nitrofluoren‐9‐yl)methoxycarbonyl group into two peptides, and a sequence‐dependant photochemical cleavage reaction are reported. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.