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Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases
Author(s) -
DiMarchi Richard D.,
Mayer John P.,
Gelfanov Vasily M.,
Tschöp Matthias
Publication year - 2018
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.3056
Subject(s) - chemistry , scope (computer science) , computational biology , biochemistry , biology , computer science , programming language
This review presents the scope of research presented in an October 2016 lecture pertaining to the award of the 2015 Max Bergmann Medal. The advancement in synthetic and biosynthetic chemistry as applied to the discovery of novel macromolecular drug candidates is reviewed. The evolution of the technology from the design, synthesis, and development of the first biosynthetic peptides through the emergence of peptide‐based incretin agonists that function by multiple biological mechanisms is exemplified by the progression of such peptides from preclinical to clinical study. A closing section highlights recent progress made in total chemical synthesis of insulin and related peptides.